The Abdominal Aortic Aneurysm and Intraluminal Thrombus: Current Concepts of Development and Treatment.
作者： Aleksandra Piechota-Polanczyk , Alicja Jozkowicz , Witold Nowak , Wolf Eilenberg , Christoph Neumayer
关键词:
摘要: The pathogenesis of the abdominal aortic aneurysm (AAA) shows several hallmarks atherosclerotic and atherothrombotic disease, but comprises an additional, predominant feature proteolysis resulting in degradation destabilization wall. This review aims to summarize current knowledge on AAA development, involving accumulation neutrophils intraluminal thrombus their central role creating oxidative proteolytic environment. Particular focus is placed controversial heme oxygenase 1/carbon monoxide nitric oxide synthase/peroxynitrite, which may exert both protective damaging effects development aneurysm. Treatment indications as well surgical pharmacological options for therapy are discussed light recent reports.
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Chung-Yu Chen, Jiann-Woei Huang, Charles Tzu-Chi Lee, Wen-Ter Lai, Yaw-Bin Huang, Long-term outcome of patients with aortic aneurysms taking low-dose aspirin: a population-based cohort study. Journal of Investigative Medicine. ,vol. 61, pp. 1004- 1012 ,(2013) , 10.2310/JIM.0B013E318297D0F9
Francisco J. Criado, Acute Thrombosis of Abdominal Aortic Aneurysm Texas Heart Institute Journal. ,vol. 9, pp. 367- 371 ,(1982)
Eric F. Steinmetz, Celine Buckley, Murray L. Shames, Terri L. Ennis, Sarah J. Vanvickle-Chavez, Dongli Mao, Lee A. Goeddel, Cherady J. Hawkins, Robert W. Thompson, Treatment With Simvastatin Suppresses the Development of Experimental Abdominal Aortic Aneurysms in Normal and Hypercholesterolemic Mice Annals of Surgery. ,vol. 241, pp. 92- 101 ,(2005) , 10.1097/01.SLA.0000150258.36236.E0
Joshua M. Thurman, Amanda M. Lenderink, Pamela A. Royer, Kathrin E. Coleman, Jian Zhou, John D. Lambris, Raphael A. Nemenoff, Richard J. Quigg, V. Michael Holers, C3a Is Required for the Production of CXC Chemokines by Tubular Epithelial Cells after Renal Ishemia/Reperfusion Journal of Immunology. ,vol. 178, pp. 1819- 1828 ,(2007) , 10.4049/JIMMUNOL.178.3.1819
P.H.M. Kuijper, H.I. Gallardo Torres, J.-W.J. Lammers, J.J. Sixma, L. Koenderman, J.J. Zwaginga, Platelet and Fibrin Deposition at the Damaged Vessel Wall: Cooperative Substrates for Neutrophil Adhesion Under Flow Conditions Blood. ,vol. 89, pp. 166- 175 ,(1997) , 10.1182/BLOOD.V89.1.166.166_166_175
R. Preston Mason, Robert F. Jacob, Ruslan Kubant, Adam Jacoby, Febee Louka, J. Jose Corbalan, Tadeusz Malinski, Effects of angiotensin receptor blockers on endothelial nitric oxide release: the role of eNOS variants British Journal of Clinical Pharmacology. ,vol. 74, pp. 141- 146 ,(2012) , 10.1111/J.1365-2125.2012.04189.X
Hazem Abdul-Hussien, Ratna G.V. Soekhoe, Ekkehard Weber, Jan H. von der Thüsen, Robert Kleemann, Adri Mulder, J. Hajo van Bockel, Roeland Hanemaaijer, Jan H.N. Lindeman, Collagen Degradation in the Abdominal Aneurysm : A Conspiracy of Matrix Metalloproteinase and Cysteine Collagenases American Journal of Pathology. ,vol. 170, pp. 809- 817 ,(2007) , 10.2353/AJPATH.2007.060522
Sharath Chandra Vikram Paravastu, Rubaraj Jayarajasingam, Rachel Cottam, Simon J Palfreyman, Jonathan A Michaels, Steven M Thomas, Endovascular repair of abdominal aortic aneurysm Cochrane Database of Systematic Reviews. ,(2014) , 10.1002/14651858.CD004178.PUB2
G Kaber, B Kaiser, D Baumgärtel‐Allekotte, BH Rauch, S Noßmann, KH Heim, AA Weber, N Nagy, JW Fischer, K Schrör, Antagonism of the antithrombotic and anti-atherosclerotic actions of aspirin by rofecoxib in the cholesterol-fed rabbit British Journal of Pharmacology. ,vol. 164, pp. 561- 569 ,(2011) , 10.1111/J.1476-5381.2011.01392.X
Tomoyuki Fujita, Koichi Toda, Ann Karimova, Shi-Fang Yan, Yoshifumi Naka, Shaw-Fang Yet, David J. Pinsky, Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nature Medicine. ,vol. 7, pp. 598- 604 ,(2001) , 10.1038/87929