Evaluation of T lymphocytes in captive african lions (Panthera leo) infected with feline immunodeficiency virus.

摘要: Objective-To determine whether FIV infection in captive African lions is associated with changes immune cell variables similar to those detected domestic cats infected FIV. Animals-5 naturally (FIV + ) and 5 not - ). Procedure-Peripheral blood samples were collected from during annual examinations conducted a 7-year period at single time point the FIV- lions. From results of CBC flow cytometry, lymphocyte subsets characterized compared. Results-Flow cytometric analysis revealed that percentage absolute number CD4 CD8 T cells significantly lower lions, compared these values In severe depletion was detected, although this did correlate clinical signs. Muscle wasting most consistent sign infection. Conclusions Clinical Relevance-Results suggest develop deficiencies, including significant decreases cells; findings dysfunction are defined for FIVE cats. It important monitor animals as measure disease progression.