Defining Appropriate Health Status and Management Programs for Specific‐Pathogen‐Free Swine for Xenotransplantation

摘要: : Swine are expected to be utilized as xenograft donors for both whole-organ and cellular transplantation. In order meet the criteria regulatory guidelines, donor animals going have free of potential zoonoses other complicating diseases. Screening will include tests viruses, bacteria, parasites, congenital defects, inapparent diseases such neoplasia or metabolic dysfunctions. The term Specific-Pathogen-Free (SPF) swine is a proprietary designation in U.S. that does not screening all appropriate organisms xenotransplantation. A program breeding conducted biomedical research facility rather than conventional farm setting. programs at should serology, microbiology, necropsy, histology parasitology. use sentinel animal monitoring one method ensure compliance. It impossible provide complete individual timely fashion prior performing transplant. Quality control measures need there reasonable confidence tissue procedure performed. suggested xenograft-defined flora used designate health status SPF avoid confusion with existing standards.