Chapter 13. Antifungal Agents

摘要: Publisher Summary This chapter analyzes antifungal agents. Based on the observations of 128 patients, griseofulvin therapy (1 g per day) was indicated for Tinea capitis (ringworm scalp), unguium , and ; this antibiotic had limited utility in treatment other Tineas caused by species Trichophyton. A correlation Trichophyton rubrum resistance to with clinical failure observed. 5% ointment a useful topical many dermatophytoses; however, it suggested that scalp nail infections systemic should always be combined local therapy. reported successful Raynaud's disease, an uncommon skin malady children. The biosynthetic origin pyrrolnitrin also studied. Because yield agent is increased when D -tryptophan added pyrrolnitrin-producing cultures, amino acid appears specific precursor. Incorporation 14 C-labeled tryptophan yielded containing 18% radioactivity. As level increases, 3-chloroindole 3-(2′-amino-3′-chloropheny1)-4-chloropyrrole were latter compound, reintroduced into fresh culture, rapidly converted pyrrolnitrin. Excess culture inhibits production substance.