Sequence Analysis of Neuroinvasive and Blood-Derived HIV-1 nef Genes
作者： Ruth Brack-Werner , Thomas Görblich , Thomas Werner , Francesca Chiodi , Lutz Gürtler
DOI: 10.1007/978-1-4615-1949-2_15
关键词:
摘要: Neurological disease associated with acquired immune deficiency syndrome (AIDS) relates to the presence of human immunodeficiency virus-1 (HIV-1) in central nervous system (CNS). In support, HIV-1, like other lentiviruses, invades CNS and can be readily isolated from cerebrospinal fluid (CSF) brain HIV-infected individuals. Several studies have identified large amounts HIV-1 proviral DNA brain, indicating that may constitute a reservoir for virus.1,2
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