Caveolins and Lung Function

摘要: The primary function of the mammalian lung is to facilitate diffusion oxygen venous blood and ventilate carbon dioxide produced by catabolic reactions within cells. However, it also responsible for a variety other important functions, including host defense production vasoactive agents regulate not only systemic pressure, but water, electrolyte acid-base balance. Caveolin-1 highly expressed in majority cell types lung, epithelial, endothelial, smooth muscle, connective tissue cells, alveolar macrophages. Deletion caveolin-1 these cells results major functional aberrations, suggesting that may be crucial homeostasis development. Furthermore, generation mutant mice under-express severe distortion with phenotypes covering practically entire spectrum known diseases, pulmonary hypertension, fibrosis, increased endothelial permeability, immune defects. In this Chapter, we outline current state knowledge regarding caveolin-1-dependent regulation functions discuss recent research findings on role various disease states, obstructive fibrotic vascular inflammatory diseases.