Torcetrapib and Dalcetrapib Safety: Relevance of PreclinicalIn VitroandIn VivoModels

作者: Eric J. Niesor , Andrea Greiter-Wilke , Lutz Müller

DOI: 10.1002/9783527673643.CH19

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参考文章(71)
Andrea Greiter-Wilke, Alexander Breidenbach, Roland Jenni, Olivier Meyer, Henry H Holzgrefe, Comparison of telemetry and high-definition oscillometry for blood pressure measurements in conscious dogs: effects of torcetrapib. Journal of The American Association for Laboratory Animal Science. ,vol. 49, pp. 464- 471 ,(2010)
ESG Stroes, JJP Kastelein, A Bénardeau, O Kuhlmann, D Blum, LA Campos, RG Clerc, EJ Niesor, Dalcetrapib: no off-target toxicity on blood pressure or on genes related to the renin-angiotensin-aldosterone system in rats. British Journal of Pharmacology. ,vol. 158, pp. 1763- 1770 ,(2009) , 10.1111/J.1476-5381.2009.00460.X
Bin Dong, Amar Bahadur Singh, Chin Fung, Kelvin Kan, Jingwen Liu, CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism Atherosclerosis. ,vol. 235, pp. 449- 462 ,(2014) , 10.1016/J.ATHEROSCLEROSIS.2014.05.931
Stephen D. McCormick, Don Bradshaw, Hormonal control of salt and water balance in vertebrates General and Comparative Endocrinology. ,vol. 147, pp. 3- 8 ,(2006) , 10.1016/J.YGCEN.2005.12.009
John W. Funder, The off-target effects of torcetrapib. Endocrinology. ,vol. 150, pp. 2024- 2026 ,(2009) , 10.1210/EN.2009-0136
Xiao Hu, Jessica D. Dietz, Chunsheng Xia, Delvin R. Knight, William T. Loging, Andrew H. Smith, Haodan Yuan, David A. Perry, Joan Keiser, Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. Endocrinology. ,vol. 150, pp. 2211- 2219 ,(2009) , 10.1210/EN.2008-1512
Charles J. Everett, Arch G. Mainous, Ivar L. Frithsen, Marty S. Player, Eric M. Matheson, Association of polychlorinated biphenyls with hypertension in the 1999-2002 National Health and Nutrition Examination Survey. Environmental Research. ,vol. 108, pp. 94- 97 ,(2008) , 10.1016/J.ENVRES.2008.05.006
James S Polakowski, Andrew J King, Thomas J Campbell, Richard A Nelson, Lee C Preusser, Anita J Kempf-Grote, Kennan C Marsh, Gary A Gintant, Bryan F Cox, Scott W Mittelstadt, Cardiovascular effects of torcetrapib in conscious and pentobarbital-anesthetized dogs. Journal of Cardiovascular Pharmacology. ,vol. 54, pp. 543- 551 ,(2009) , 10.1097/FJC.0B013E3181BFB158
Katsuhiko Yoshizawa, Allison Heatherly, David E. Malarkey, Nigel J. Walker, Abraham Nyska, A Critical Comparison of Murine Pathology and Epidemiological Data of TCDD, PCB126, and PeCDF: Toxicologic Pathology. ,vol. 35, pp. 865- 879 ,(2007) , 10.1080/01926230701618516