Prognostic impact of the mean platelet volume/platelet count ratio in terms of survival in advanced non-small cell lung cancer.

摘要: Abstract Background Mean platelet volume (MPV) is a index. Classically, MPV was recognized as hallmark of activation. Recent studies have revealed that the and MPV/platelet count (PC) ratio can predict long-term mortality in patients with ischemic cardio-vascular disease. In addition, these indices were correlated pathophysiological characteristics various disorders, including malignant tumors. Patients methods We retrospectively analyzed hematological advanced non-small cell lung cancer (NSCLC). The aim this study to evaluate contribution survival patients. Results A total 268 enrolled study. median age 68 years (range: 31–87 years). compared between NSCLC group an age- sex-matched comparator group. significantly decreased contrast, PC increased Consequently, MPV/PC also (0.397 vs. 0.501). receiver operating (ROC) curve analysis, associated sensitivity 62.3% specificity 74.6% at cutoff value 0.408730 (area under [AUC], 0.72492)]. Univariate analysis overall (OS) shorter low than other (median time [MST]: 10.3 months 14.5 months, log-rank, P =0.0245). Multivariate confirmed independent unfavorable predictive factor for OS (hazard [HR]: 1.668, 95% confidence interval [CI]: 1.235–2.271, =0.0008). Conclusion These data clearly demonstrate closely NSCLC.