2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.
作者： Hongliang Duan , Jin Zheng , Qinglin Lai , Zheng Liu , Guanghui Tian
DOI: 10.1016/J.BMCL.2009.03.125
关键词:
摘要: In our efforts to minimize the side effects associated with low selectivity against other PDE isozymes, a novel class of 2-phenylquinazolin-4(3H)-one derivatives were designed and prepared as potent PDE5 inhibitors high PDE6. The syntheses SAR studies such molecules reported.
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Andrew W Stamford, Chapter 6. Phosphodiesterase 5 inhibitors Annual Reports in Medicinal Chemistry. ,vol. 37, pp. 53- 64 ,(2002) , 10.1016/S0065-7743(02)37007-6
Helmut Haning, Ulrich Niewöhner, Erwin Bischoff, Phosphodiesterase type 5 (PDE5) inhibitors. Progress in Medicinal Chemistry. ,vol. 41, pp. 249- 306 ,(2003) , 10.1016/S0079-6468(02)41007-7
Helmut Haning, Ulrich Niewöhner, Thomas Schenke, Thomas Lampe, Alexander Hillisch, Erwin Bischoff, Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors Bioorganic & Medicinal Chemistry Letters. ,vol. 15, pp. 3900- 3907 ,(2005) , 10.1016/J.BMCL.2005.05.090
Masanori Tobe, Yoshiaki Isobe, Hideyuki Tomizawa, Takahiro Nagasaki, Hirotada Takahashi, Tominaga Fukazawa, Hideya Hayashi, Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation Bioorganic & Medicinal Chemistry. ,vol. 11, pp. 383- 391 ,(2003) , 10.1016/S0968-0896(02)00440-6
Timur Güngör, Ying Chen, Rajasree Golla, Zhengping Ma, James R. Corte, John P. Northrop, Bin, John K. Dickson, Terry Stouch, Rong Zhou, Susan E. Johnson, Ramakrishna Seethala, Jean H. M. Feyen, Synthesis and Characterization of 3-Arylquinazolinone and 3-Arylquinazolinethione Derivatives as Selective Estrogen Receptor Beta Modulators Journal of Medicinal Chemistry. ,vol. 49, pp. 2440- 2455 ,(2006) , 10.1021/JM0509389
Michael F. Marmor, Robert Kessler, Sildenafil (Viagra) and Ophthalmology Survey of Ophthalmology. ,vol. 44, pp. 153- 162 ,(1999) , 10.1016/S0039-6257(99)00079-X
David P. Rotella, Phosphodiesterase 5 inhibitors: current status and potential applications Nature Reviews Drug Discovery. ,vol. 1, pp. 674- 682 ,(2002) , 10.1038/NRD893
Adam F. Littke, Lothar Schwarz, Gregory C. Fu, Pd/P(t-Bu)3: A mild and general catalyst for Stille reactions of aryl chlorides and aryl bromides Journal of the American Chemical Society. ,vol. 124, pp. 6343- 6348 ,(2002) , 10.1021/JA020012F
Chia-Chun Chen, Chun-Chia Yeh, Chun-Ho Chen, Min-Yuan Yu, Hsiang-Lin Liu, Jih-Jen Wu, Kuei-Hsein Chen, Li-Chyong Chen, Jin-Yuan Peng, Yang-Fang Chen, Catalytic Growth and Characterization of Gallium Nitride Nanowires Journal of the American Chemical Society. ,vol. 123, pp. 2791- 2798 ,(2001) , 10.1021/JA0040518
Jacob Rajfer, William J. Aronson, Peggy A. Bush, Frederick J. Dorey, Louis J. Ignarro, Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission New England Journal of Medicine. ,vol. 326, pp. 90- 94 ,(1992) , 10.1056/NEJM199201093260203