Role of Astrocytes in Delayed Neuronal Death: GLT-1 and its Novel Regulation by MicroRNAs.
作者： Yi-Bing Ouyang , Lijun Xu , Siwei Liu , Rona G. Giffard
DOI: 10.1007/978-3-319-08894-5_9
关键词:
摘要: Astrocytes have been shown to protect neurons from delayed neuronal death and increase their survival in cerebral ischemia. One of the main mechanisms astrocyte protection is rapid removal excess glutamate synaptic sites by astrocytic plasma membrane transporters such as GLT-1/EAAT-2, reducing excitotoxicity. Astrocytic mitochondrial function essential for normal GLT-1 function. Manipulating thus an important strategy enhance improve outcome following Increasing evidence supports involvement microRNAs (miRNA), some them being astrocyte-enriched, regulation This chapter will first update information about astrocytes, GLT-1, mitochondria, death. Then we focus on two recently reported astrocyte-enriched miRNAs (miR-181 miR-29 families), effects mitochondria well after
springer.com
sci-hub.st 参考文章(100)
Ludmila A. Voloboueva, Sang Won Suh, Raymond A. Swanson, Rona G. Giffard, Inhibition of mitochondrial function in astrocytes: implications for neuroprotection Journal of Neurochemistry. ,vol. 102, pp. 1383- 1394 ,(2007) , 10.1111/J.1471-4159.2007.04634.X
Lijun Xu, John F. Emery, Yi-Bing Ouyang, Ludmila A. Voloboueva, Rona G. Giffard, Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia. ,vol. 58, pp. 1042- 1049 ,(2010) , 10.1002/GLIA.20985
Takaaki Kirino, Delayed neuronal death Neuropathology. ,vol. 20, pp. 95- 97 ,(2000) , 10.1046/J.1440-1789.2000.00306.X
Ludmila A. Voloboueva, John F. Emery, Xiaoyun Sun, Rona G. Giffard, Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin FEBS Letters. ,vol. 587, pp. 756- 762 ,(2013) , 10.1016/J.FEBSLET.2013.01.067
Jifang Tao, Hao Wu, Quan Lin, Weizheng Wei, Xiao-Hong Lu, Jeffrey P Cantle, Yan Ao, Richard W Olsen, X William Yang, Istvan Mody, Michael V Sofroniew, Yi E Sun, Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration. The Journal of Neuroscience. ,vol. 31, pp. 8306- 8319 ,(2011) , 10.1523/JNEUROSCI.0567-11.2011
Carol Kaiser Petito, John-Paul Olarte, Brenda Roberts, Thaddeus S. Nowak, William A. Pulsinell, Selective Glial Vulnerability following Transient Global Ischemia in Rat Brain Journal of Neuropathology & Experimental Neurology. ,vol. 57, pp. 231- 238 ,(1998) , 10.1097/00005072-199803000-00004
Huating Wang, Ramiro Garzon, Hao Sun, Katherine J. Ladner, Ravi Singh, Jason Dahlman, Alfred Cheng, Brett M. Hall, Stephen J. Qualman, Dawn S. Chandler, Carlo M. Croce, Denis C. Guttridge, NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma Cancer Cell. ,vol. 14, pp. 369- 381 ,(2008) , 10.1016/J.CCR.2008.10.006
Chang-Zheng Chen, Ling Li, Harvey F Lodish, David P Bartel, MicroRNAs Modulate Hematopoietic Lineage Differentiation Science. ,vol. 303, pp. 83- 86 ,(2004) , 10.1126/SCIENCE.1091903
Stephen A. Bernard, Timothy W. Gray, Michael D. Buist, Bruce M. Jones, William Silvester, Geoff Gutteridge, Karen Smith, Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia The New England Journal of Medicine. ,vol. 346, pp. 557- 563 ,(2002) , 10.1056/NEJMOA003289
Maria C. Longuemare, Mary Pat Hill, Raymond A. Swanson, Glycolysis can prevent non-synaptic excitatory amino acid release during hypoxia. Neuroreport. ,vol. 5, pp. 1789- 1792 ,(1994) , 10.1097/00001756-199409080-00026