Identification of T cell peptides from C gamma 2ab involved in IgG2ab T cell-induced allotypic suppression. Relationship with the MHC haplotype of the suppressor T cell-donor Igha mice.

摘要: Using the algorithm of peptidic self-model we selected, from constant part IgG2ab polypeptidic heavy chain, four peptides susceptible to being recognized by T cells Igha mice that prevent expression. Among these peptides, two were capable enhancing in vivo this cell activity almost as well whole allotype. One C gamma 2ab-248-263, located CH3 domain IgG2ab, was effective H-2d mice, while other one, 2ab-103-118, hinge region efficient H-2b mice. This demonstrates for first time suppression involves TCR effector and derived allotype presented context MHC molecules target cells, presentation specificity dependent on haplotype. The availability will allow us further understand role class I and/or II suppression.