Targeted Delivery of Aptamers and siRNAs for HIV Prevention and Therapies in Humanized Mice

摘要: Combinatorial drug therapies utilizing the HAART approach have drastically reduced HIV/AIDS fatality rates. However, there is yet no complete cure for HIV. Drug toxicity and generation of viral escape mutants also continue to pose problems during therapy. Therefore, alternative approaches employing novel antiviral molecules need be explored. In this regard, RNA-based that employ siRNAs aptamers show considerable promise. A number siRNA targeted either (e.g., tat, rev, RT, env) or cell transcripts CCR5 CXCR4) were successfully tested in experimental settings. Similarly, RNA against RT gp120) cellular receptors CD4) shown promising results. major obstacle these reach clinical application has been their inefficient vivo delivery virus susceptible cells. Recent strategies overcome stumbling block utilized methods exploit systemic nanoparticle aptamer-siRNAs conjugates specific vivo. regard humanized mice instrumental derive important preclinical data later human trials. Here we summarize recent developments anti-HIV therapeutics.