Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice.
作者： Xi-Feng Zhang , Teng Zhang , Liu Wang , Hong-Ying Zhang , Yong-De Chen
DOI: 10.1007/S11033-013-2769-Y
关键词:
摘要: We previously demonstrated that the effects of diethylhexyl phthalate (DEHP) alter reproduction function on male mice. Immature mice were treated daily with DEHP from postnatal day 7–21, 7–35, 7–49, in a dose-dependent manner. As results, both quality and quantity spermatozoa decreased 60-day-old The results by RT-PCR analysis indicated DDx3Y, Usp9Y, RBM, E1F1AY, EGF, FSHR EGFR genes down-regulated, LHR, Cyp17a1 Cyp19a1 down-regulated response to DEHP. These selected based their markedly increased or expression levels. However, had no effect meiotic process recombination levels mouse germ cells. Treatment induced histopathological changes testes. Taken together, these provide new insight into molecular mechanisms underlying detrimental impacts humans wildlife.
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sci-hub.se 参考文章(35)
Jasna Bošnir, Dinko Puntarić, Ivo Škes, Maja Klarić, Spomenka Šimić, Ivan Zorić, None, Migration of phthalates from plastic products to model solutions. Collegium Antropologicum. ,vol. 27, pp. 23- 30 ,(2003)
Dana W. Kolpin, Edward T. Furlong, Michael T. Meyer, E. Michael Thurman, Steven D. Zaugg, Larry B. Barber, Herbert T. Buxton, Response to Comment on “Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999−2000: A National Reconnaissance” Environmental Science & Technology. ,vol. 36, pp. 1054- 1054 ,(2002) , 10.1021/ES020136S
M Anas, Effect of mono-(2-ethylhexyl) phthalate on bovine oocyte maturation in vitro. Reproductive Toxicology. ,vol. 17, pp. 305- 310 ,(2003) , 10.1016/S0890-6238(03)00014-5
D.K. Agarwal, R.R. Maronpot, J.C. Lamb, W.M. Kluwe, Adverse effects of butyl benzyl phthalate on the reproductive and hematopoietic systems of male rats. Toxicology. ,vol. 35, pp. 189- 206 ,(1985) , 10.1016/0300-483X(85)90015-0
Deepak Agarwal, W. H. Lawrence, James Turner, John Autian, Effects of parenteral di-(2-ethylhexyl)phthalate (DEHP) on gonadal biochemistry, pathology, and reproductive performance of mice. Journal of Toxicology and Environmental Health. ,vol. 26, pp. 39- 59 ,(1989) , 10.1080/15287398909531232
S. Hadi Anjamrooz, Mansoureh Movahedin, Taki Tiraihi, S. Javad Mowla, In vitro effects of epidermal growth factor, follicle stimulating hormone and testosterone on mouse spermatogonial cell colony formation. Reproduction, Fertility and Development. ,vol. 18, pp. 709- 720 ,(2006) , 10.1071/RD05126
A. Dalman, H. Eimani, S.K. Ashtiani, M.R. Valojerdi, P. Eftekhari-Yazdi, A. Shahverdi, H. Sepehri, Effect of mono-(2-ethylhexyl) phthalate (MEHP) on resumption of meiosis, in vitro maturation and embryo development of immature mouse oocytes. Biofactors. ,vol. 33, pp. 149- 155 ,(2008) , 10.1002/BIOF.5520330207
H.F. Schteingart, S.B. Meroni, E.H. Pellizzari, A.Loaiza Pérez, S.B. Cigorraga, Regulation of Sertoli cell aromatase activity by cell density and prolonged stimulation with FSH, EGF, insulin and IGF-I at different moments of pubertal development The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 52, pp. 375- 381 ,(1995) , 10.1016/0960-0760(94)00181-K
Robert Kavlock, Kim Boekelheide, Robert Chapin, Michael Cunningham, Elaine Faustman, Paul Foster, Mari Golub, Rogene Henderson, Irwin Hinberg, Ruth Little, Jennifer Seed, Katherine Shea, Sonia Tabacova, Rochelle Tyl, Paige Williams, Timothy Zacharewski, NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate Reproductive Toxicology. ,vol. 16, pp. 529- 653 ,(2002) , 10.1016/S0890-6238(02)00032-1
Oliana Carnevali, Luca Tosti, Claudia Speciale, Chun Peng, Yong Zhu, Francesca Maradonna, DEHP Impairs Zebrafish Reproduction by Affecting Critical Factors in Oogenesis PLoS ONE. ,vol. 5, pp. e10201- ,(2010) , 10.1371/JOURNAL.PONE.0010201