作者: G. Pacheco-Rodriguez , Naoko Morinaga , Masatoshi Noda , J. Moss , M. Vaughan
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摘要: Cholera (CT) and heat labile E. coli (LT) enterotoxins are members of the AB5 family bacterial toxins that contain one catalytically active A subunit associated with a complex five B subunits. The subunits CT LT bind receptor, ganglioside GM1, at cell surface as required first step in entry holotoxin into target cells. is processed catalytic A1 linker A2 segments. holotoxin-receptor internalized transported to endoplasmic reticulum before release protein cytosol. ADP-ribosyltransferase activity critical determinant toxin potency. When bound GTP, all Arfs allosteric activators vitro. importance such interactions intoxication cells is, however, less clear. Recent reports suggest possibilities for clinically effective prevention action by interference initial binding GM1 receptor or inhibition CTA1 intestinal mucosa