Epilepsy treatment in developing countries: drug treatment.

作者: Carlos Acevedo , Keryma Acevedo

DOI: 10.1016/B978-0-444-52899-5.00038-1

关键词:

摘要: Abstract Approximately 70% of patients with epilepsy achieve seizure freedom using antiepileptic drugs. Their cost has increased steadily in recent decades, restricting drug access for many developing countries. Implementation containment policies is crucial. One approach includes the use generic drugs, which are widely prescribed because their lower price. However, it must be considered that 80–125% range between pharmacokinetic parameters and innovative formulations wide, there risks breakthrough seizures side-effects when switching brand Sometimes this even performed without consent both patient physician. No state regarding generics available now, but specific recommendations from societies worldwide. Specific addressing these issues needed, medications a well-controlled considered. In addition, efforts directed to reduce treatment gap countries, comprising failure accurately diagnose, study, treat patients, further needed. Issues can approached through organized interventions such as national programs assuring universal at least older

参考文章(43)
Javier González de Dios, Carlos Ochoa Sangrador, Ángel Pérez Sempere, Fármacos genéricos en el tratamiento de la epilepsia Revista De Neurologia. ,vol. 41, pp. 676- 683 ,(2005) , 10.33588/RN.4111.2005395
Marvin C. Meyer, Arthur B. Straughn, Eric J. Jarvi, George C. Wood, Francis R. Pelsor, Vinod P. Shah, The Bioinequivalence of Carbamazepine Tablets with a History of Clinical Failures Pharmaceutical Research. ,vol. 9, pp. 1612- 1616 ,(1992) , 10.1023/A:1015872626887
Robert A Scott, Samden D Lhatoo, Josemir WAS Sander, None, The treatment of epilepsy in developing countries: where do we go from here? Bulletin of The World Health Organization. ,vol. 79, pp. 344- 351 ,(2001) , 10.1590/S0042-96862001000400012
Barbara C Jobst, Gregory L Holmes, Prescribing antiepileptic drugs: should patients be switched on the basis of cost? CNS Drugs. ,vol. 18, pp. 617- 628 ,(2004) , 10.2165/00023210-200418100-00001
Michael D. Privitera, Generic Antiepileptic Drugs: Current Controversies and Future Directions Epilepsy Currents. ,vol. 8, pp. 113- 117 ,(2008) , 10.1111/J.1535-7511.2008.00261.X
G. Krämer, A. Biraben, M. Carreno, A. Guekht, G.J. de Haan, J. Jędrzejczak, D. Josephs, K. van Rijckevorsel, G. Zaccara, Current approaches to the use of generic antiepileptic drugs Epilepsy & Behavior. ,vol. 11, pp. 46- 52 ,(2007) , 10.1016/J.YEBEH.2007.03.014
Wim Van Paesschen, Henri Hauman, Lieven Lagae, The use of generic medication in epilepsy: A review of potential issues and challenges European Journal of Paediatric Neurology. ,vol. 13, pp. 87- 92 ,(2009) , 10.1016/J.EJPN.2008.07.007
Lisa S. Haskins, Kenneth J. Tomaszewski, Pamela Crawford, Patient and physician reactions to generic antiepileptic substitution in the treatment of epilepsy Epilepsy & Behavior. ,vol. 7, pp. 98- 105 ,(2005) , 10.1016/J.YEBEH.2005.04.005
Andrew N. Wilner, Therapeutic equivalency of generic antiepileptic drugs: results of a survey. Epilepsy & Behavior. ,vol. 5, pp. 995- 998 ,(2004) , 10.1016/J.YEBEH.2004.05.011
H Meinardi, RA Scott, R Reis, None, The treatment gap in epilepsy: the current situation and ways forward. Epilepsia. ,vol. 42, pp. 136- 149 ,(2008) , 10.1046/J.1528-1157.2001.32800.X