Glucocorticoid and mineralocorticoid receptor mRNA expression in rat brain.

摘要: In the rat brain, binding of corticosterone is mediated through two receptor types, type I and II receptor, which are presumed to be encoded by genes designated as MR GR, respectively. We have studied regulation these receptors glucocorticoids, utilizing a cytosol assay. addition, we employed molecular probes for GR measure mRNAs. The level uniform across several brain regions, expression (type II) mRNA. contrast, concentrated in hippocampus, I) mRNA similarly shows higher hippocampus than other regions studied. Removal endogenous glucocorticoids adrenalectomy (ADX) induces an increase, administration results decrease, hippocampus; however, no significant changes or levels seen with treatments. diurnal variation serum intact rats correlated circadian while unaffected. Thus, capacity elicited differing steroid conditions cannot attributed modulation steady state