Nuclear Factor κB-Dependent Histone Acetylation is Specifically Involved in Persistent Forms of Memory

摘要: Memory consolidation requires gene expression regulation by transcription factors, which eventually may induce chromatin modifications as histone acetylation. This mechanism is regulated acetylases and deacetylases. It not yet clear whether memory always recruits acetylation or it only engaged in more persistent memories. To address this question, we used different strength of training for novel object recognition task mice. Only strong induced a long-lasting an increase hippocampal H3 Histone acetylase inhibition the hippocampus during impaired persistence, whereas deacetylase caused weak to persist. Nuclear factor κB (NF-κB) persistence and, concomitantly, reduced general level Accordingly, found important at specific NF-κB-regulated promoter region Camk2d gene, was reversed NF-kB inhibition. These results show first time that molecular signature enduring