Increased frequency of circulating regulatory T cells in patients with acute cerebral hemorrhage.
作者： Lijin Shi , Jie Qin , Bo Song , Qing Mei Wang , Rui Zhang
DOI: 10.1016/J.NEULET.2015.02.042
关键词:
摘要: Abstract Cerebral hemorrhage (ICH) is a serious stroke subtype, currently lacking effective treatment. Recent research has shown that CD4 + CD25 FOXP3 regulatory T cells (Tregs) play key role in the immune response of ischemic stroke. However, Tregs human hemorrhagic are poorly investigated. In this study, total 90 ICH patients and 60 healthy controls were recruited. The frequency circulating Tregs, plasma levels TGF-β IL-10, severity neural dysfunction investigated at different time points post ICH. We found peripheral was significantly increased, accompanied by boosted activated cells. Importantly, elevation with severe much higher than less-severe patients, suggesting disease affects to exert function. Furthermore, both IL-10 related function also increased blood patients. Our results demonstrate Tregs-mediated imbalance might affect development ICH, suggest may be used as tools targets cellular immunotherapy effectively treat acute
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