Ki-67 as a prognostic marker in mantle cell lymphoma-consensus guidelines of the pathology panel of the European MCL Network

摘要: Mantle cell lymphoma (MCL) has a heterogeneous clinical course and is mainly an aggressive B non-Hodgkin lymphoma; however, there are some indolent cases The Ki-67 index, defined by the percentage of Ki-67-positive cells on histopathological slides, been shown to be very powerful prognostic biomarker. pathology panel European MCL Network evaluated methods assess index including stringent counting, digital image analysis, estimation eyeballing. Counting 2 × 500 gold standard since this value predict survival in prospective randomized trials Network. Estimation eyeballing analysis showed poor concordance with (concordance correlation coefficients [CCC] between 0.29 0.61 for CCC 0.24 0.37 two respectively). reduced number (2 100 cells) high interobserver agreement (CCC = 0.74). Pitfalls discussed guidelines recommendations assessing given.