Pretreatment prognostic factors in carcinoma of the uterine cervix: A multivariable analysis of the effect of age, stage, histology and blood counts on survival

摘要: Abstract From January, 1953 through December, 1977, 910 previously untreated patients with invasive carcinoma of the uterine cervix (Stages IB-IVB) were seen at Yale-New Haven Medical Center and affiliated hospitals. An extensive retrospective analysis was undertaken in an attempt to identify prognostically significant pretreatment factors. The studied uniformly staged according current FIGO recommendations majority had been treated under standardized protocols combining external beam radiation therapy intracavitary radium. Pretreatment parameters, including prior medical illnesses, gross tumor characteristics, histology, blood parameters studied, employing stepwise Cox regression analyses possible effects all factors two-way interactions among on survival, disease-free survival freedom from local-regional failure, controlling for stage disease. stage, patient age diagnosis, neutrophil count hematocrit, position, subtotal hysterectomy, history diabetes mellitus number pregnancies found have prognostic significance. When other disease controlled for, increased size associated decreased control rates.