A morphological study of experimental rabbit staphylococcal endocarditis and aortitis. I. Formation and effect of infected and uninfected vegetations on the aorta.

摘要: In this study the development of sterile thrombic vegetations on aorta resulting from catheterization and effect subsequent infection with Staphylococcus aureus were examined by light electron microscopy. Thrombi various sizes, comprising fibrin, platelets a few leucocytes erythrocytes, develop damaged surface minimal changes in underlying aortic wall. After intravenous inoculation Staph. most become infected, as shown presence bacterial colonies, wall is markedly inflamed. The inflammatory cells invade base cause swelling plus disruption elastic laminae ulceration luminal some cases. This structural damage appears to be direct result lesions surface.