Hypoxia‐inducible factor 1α/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis

摘要: Hypoxia-inducible factor (HIF)-1alpha is a transcription that promotes ischaemia-driven angiogenesis. The aim of this study was to determine the relation HIF-1alpha vascular endothelial growth (VEGF; an important angiogenic molecule in brain tumours), p53 expression, angiogenesis, proliferative potential and clinical outcome large series diffuse astrocytomas. Expression HIF-1alpha, VEGF, Ki-67 (a proliferation-associated marker) determined immunohistochemically 83 adult patients with supratentorial Microvessels, highlighted by means anti-CD34 immunohistochemistry, were enumerated computer-assisted image analysis. Although VEGF expressed majority cases, their levels increased significantly increasing grade potential. positively correlated microvessel counts total area presence rounder vessel sections. There positive correlation expression astrocytomas anaplastic In univariate analysis, both associated shortened survival entire cohort, but lost significance when grades II/III IV analysed separately. Multivariate analysis revealed combination significant prognostic indicator. may be used refine information provided Its adverse effect most likely mediated hypoxia, driving force for accumulation.