Production of Medicines from Engineered Proteins in Plants: Proteins for a New Century

摘要: Recombinant proteins have already delivered major benefits to human health in the relatively short time they been available. Plant-based production strategies for these proteins—sometimes called molecular pharming—are becoming widespread and offer utility, as well overcoming some of drawbacks microbial mammalian systems. Flexible rapid engineering methods, combined with high volume expression protein isolation, or seed-based long-term storage, many options medically-relevant direct people who need use them. Metabolic infectious disease treatments are among early targets, but cancer treatment, circulatory aliments, allergy reduction, wound repair tissue regeneration support may result from produced plant Selected samples projects provided illustrate current directions, including first FDA approved recombinant drug treat a disease. Other examples aimed at communicable diseases, cancer, heart disease, included. When safety efficacy demonstrated, adherence appropriate regulatory biosafety frameworks, plant-derived high-volume cost-effective delivery systems medical applications this century.