Intrarectal Quinimax® (an association of Cinchona alkaloids) for the treatment of Plasmodium falciparum malaria in children in Niger: efficacy and pharmacokinetics

摘要: In an attempt to avoid the complications associated with intramuscular quinine administration, we assessed intrarectal route. Sixty-six children aged from 2 10 years Plasmodium falciparum malaria were included in study, which took place Niamey, Niger. Fifty-five given 20 mg/kg of diluted injectable form Quinimax® (a quinine, quinidine, cinchonine, cinchonidine association) intrarectally. A further 11 treated 12·5 same solution by All twice a day for 3 d. Blood samples drawn (15 intrarectally and 5 intramuscularly) kinetic study. Both modes administration well tolerated. Mean fever clearance times (±standard errors) 48·6 ± 2·7 h 35·9 2·2 groups, respectively (P = 0·05). parasite (± standard mean achieve 50% reduction parasitaemia similar after (46·5 5·7 7·8 0·9 respectively) (27·4 3·6 8·7 1·7 h, respectively). Tmax. (2·7 0·4 h) did not differ significantly value (1·1 0·6 h), but Cmax. area under concentration-time curve 0 48 lower (4·9 mg/L 230·0 9·6 mg/L.h, than (9·1 1·2 356·0 4·2 < 0.001). Compared route, bioavailability was 40%. The tolerability efficacy this alkaloids association administered route satisfactory, while should be improved use formulation specifically adapted