Study of microbial contamination and dosing accuracy of oral dispensers

摘要: Summary Background and objective:  The optimal administration of liquid medications requires accurate dose delivery. This is particularly important in the treatment infants children, as well elderly people, who are more sensitive to dosage errors. Previous studies revealed significant inaccuracies with measuring spoons. Oral syringes therefore generally recommended instead. There no data on efficacy standard cleaning techniques, consequently degree microbial contamination associated repeated use oral syringes. study aimed investigate level types microorganisms found dispensers subjected simulated in-use conditions. In addition, dosing accuracy compared that spoons supplied designed for specific medications. Methods:  Exadoral® 5 mL from B. Braun Melsungen AG (Melsungen, Germany) were conditions assay. Six different representing substance classes included. test lasted 4–15 days two four doses withdrawn according recommendations. Dosing was assessed using six representative amoxicillin suspensions available German market after withdrawing 1·25, 2·5 correspond ¼, ½ full spoons. Results discussion:  Low counts Micrococcus luteus, lylae, Staphylococcus epidermidis, chromogenes Bacillus species Candida lusitaniae may contaminate interior surface dispenser, but count below accepted limit permissible drinking water over whole period. Hence, be considered safe, provided procedures followed exactly. Moreover, dispensers, although not specifically tested medication, showed much higher comparison spoons. Conclusion:  present devices safe medication. Pharmacists physicians should encourage their patients routinely practice.