Anti-inflammatory and toxicity studies of atranorin extracted from Cladina kalbii Ahti in rodents
作者： Marcelia Garcez Dória de Melo , Adriano Antunes de Souza Araújo , Mairim Russo Serafini , Larissa Feitosa Carvalho , Marília Santos Bezerra
DOI: 10.1590/S1984-82502011000400024
关键词:
摘要: Atranorin (ATR) is the main compound from lichen Cladina kalbii Ahti, which grows in arid regions of northeastern Brazil. This study was conducted to evaluate anti-inflammatory and toxicological properties ATR. To properties, paw edema induced by injecting 0.1 mL carrageenan into subplantar region right hind rats, leukocyte migration injection 500 µL peritoneal cavity mice. In addition, we determined ATR cytotoxicity L929 cells MTT assay acute (5 g/kg-single dose) subchronic (50 mg/kg-30 days) toxicity tests Wistar rats. The results showed that (100 mg/kg 200 mg/kg) exhibited significant activity (paw migration). test, animals hypoactivity lethargy during initial period (first 6 hours) increase total protein, indirect bilirubin, alkaline phosphatase after 14 days ATR-treated male test revealed increases globulin, gamma-glutamyl transferase, phosphatase, direct bilirubin female Histological analysis no changes architecture morphology organs. These suggest has activity, with or cytotoxicity.
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