The Renaissance of CYP17 Inhibitors for the Treatment of Prostate Cancer
作者： Qingzhong Hu , Rolf W. Hartmann
DOI: 10.1016/B978-0-12-396521-9.00011-5
关键词:
摘要: Prostate cancer ranks second worldwide in terms of incidence and is responsible for a large number cancer-related deaths. It has been shown that up to 80% prostate depends on androgen stimulation. Although some cases progress castration resistance, recent studies demonstrate they are still driven. The inhibition CYP17, which the crucial enzyme biosynthesis, novel approach hormone therapy. Evolved from initial off-label use ketoconazole recently approved abiraterone four more drug candidates clinical trials, improvement CYP17 inhibitors provides patients with an increased overall survival better quality life.
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