Prostate cancer screening markers

摘要: Abstract Prostate cancer is the most frequent new diagnosis in Western world. Prostate-specific antigen (PSA) was shown to be an adequate tool prostate screening. However, men with a PSA level between 4.0 and 10 ng/ml its predictive value low. serum levels are poorly correlated grade stage of cancer, clinically significant cancers have been found patients lower than 4.0 ng/ml. The widespread use screening programs led over-diagnosis unnecessary biopsies. Consequently, there need for instruments that likely improve specificity subjects low PSA. Potential biomarkers related conventional PSA, such as free density, velocity complexed intact nicked benign pro well insulin-like growth factor 1 binding protein, human glandular kallikrein 2 reviewed. Promising urinary markers early detection glutathione-S transferase P1 gene (GSTP-1), 8-hydroxydeoxyguanosine (8-OHdG), differential display code 3 (DD3), uPM3, telomerase, which described during last years reviewed this article. advantages limitations discussed.