Synthesis of Enantiopure Di(Tert‐Butyl) (2S,4S)‐4‐Hydroxy‐6‐Oxo‐1,2‐Piperidinedicarboxylate. A Useful Building Block for the Preparation of 4‐Hydroxypipecolate Derivatives
作者： Olivier Chaloin , Frédéric Cabart , Julien Marin , Haixiang Zhang , Gilles Guichard
DOI: 10.1002/0471264229.OS085.16
关键词:
摘要: N-alpha-tert-Butoxycarbonyl-L-aspartic acid alpha-tert-butyl ester 2,2-Dimethyl-1,3-dioxane-4,6-dione N-(3-Dimethylaminopropyl)-N′-ethylcarbodimide hydrochloride 2-tert- Butoxycarbonylamino-4-(2,2-dimethyl-4,6-dioxo-[1,3]dioxin-5-yl)-4-oxo-butyric tert-butyl ester Di(tert-butyl)(2S)-4,6-dioxo-1,2-piperidinedicarboxylate Sodium borohydride Di(tert-butyl)(2S,4S)-4-hydroxy-6-oxo-1,2-piperidinedicarboxylate Keywords: hydroxypipecolate derivatives; enantiopure; chiral tetramic acids; meldrum's acid; N-Protected alpha-amino acids; three-step procedure; lactam; ring opening; lactone; waste disposal
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