Hypotensive action of commercial intravenous amiodarone and polysorbate 80 in dogs.

摘要: Commercial intravenous amiodarone has been reported to have antiarrhythmic actions and cause only mild hypotension in humans. In the dog, however, was observed severe hypotension. Since commercial is compound (50 mg/ml) dissolved water with polysorbate 80 (Tween 80) (100 mg/kg), effects of ethanol (5 mg/kg) (10 were studied individually, combination anesthetized dogs. caused at least a 60% drop mean blood pressure left ventricular maximum dP/dt for 30 min, whereas did not. The not principally due peripheral vasodilation. Therefore, dogs diluent major resulting from amiodarone. These studies show that produces results different than previously Therefore: (a) canine models studying would produce complicated by hypotension; (b) an inert substance, but potent cardiac depressant.