Randomised, double-blind and placebo-controlled study of the effect of a synbiotic dairy product on orocecal transit time in healthy adult women.

摘要: Objective: To evaluate oro-cecal intestinal transit time (ITT) before and after administration of a dairy product containing Bifidobacterium BB12, Lactobacillus casei CRL 431 fiber in healthy women. Methods: A prospective, randomised, double-blind cross-over study with 4-phase design (run-in: 0 [T0], two intervention periods: 1 [T1] 3 [T3] wash-out: 2, [T2]) was performed. Participants were asked about bowel movement consumption. ITT assessed by the carmine red dye method. Results: Mean age 40.7 years (n = 102 women; 83 completed study). In women initial (IITT) ≥ 48 h consuming synbiotic product, mean IITT final (FITT) 86.9 ± 38.5 51.2 29.8 (-40.9%), as compared to control yoghurt (IITT, 80.8 31.7 h; FITT, 69.5 31.5 -13.8%) (p 0.001). functional constipation 57.0 30.0 such figure increased 2.8 consumption (FITT, 59.8 0.2 +4.9%). Conversely, who received 69.0 49.6 h, -27.5% decrease 19 later 50.0 27.5 p 0.023). Enteric lactic flora stabilization significantly higher initially consumed < 0.1). Conclusion: decreased product. Such beneficial effect more evident constipation.