Carbonylation of the cytoskeletal protein actin leads to aggregate formation

摘要: Protein carbonylation is a common feature in cells exposed to oxidants, leading protein dysfunction and aggregates. Actin, which involved manifold cellular processes, sensitive target this oxidative modification. T-cell proteins have been widely described be targets modifications. The aim of work was test whether the formation aggregates contributes impaired proliferation Jurkat after stress actin as major oxidation-prone cytoskeletal an integral part such We used cells, established model, showing along with decrease proteasome activity. presence these inhibits even under conditions not influencing viability. As conclusion, we propose that environment leads contributing functional impairment.