Upregulation of transferrin receptor 2 and ferroportin 1 mRNA in the liver of patients with chronic hepatitis C.
作者： MASAKI TAKEO , YOSHINAO KOBAYASHI , NAOKI FUJITA , NAOHITO URAWA , MOTOH IWASA
DOI: 10.1111/J.1440-1746.2005.03770.X
关键词:
摘要: Background: Iron accumulation has been reported to be associated with progression of liver injury. The mechanism iron in the is not known. In present study, hepatic messenger RNA (mRNA) expression transferrin receptor (TfR)1, TfR2, and ferroportin (FP)1 was measured patients chronic hepatitis (CH). Methods: Eleven CH-B 43 CH-C were enrolled. All underwent biopsy. Hepatic TfR1, TfR2 FP1 mRNA analyzed using a real-time polymerase chain reaction. Total score (THIS) evaluated by Prussian blue staining. Results: Serum ferritin concentration significantly higher than CH-B. Values THIS ≥5 observed only (44% patients). level 10–26-fold TfR1 level. patients. well correlated THIS. Conclusions: more severe CH-C. Upregulation transporters may contribute
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