Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer
作者： Ryan A Hutchinson , Richard A Adams , Darragh G McArt , Manuel Salto-Tellez , Bharat Jasani
DOI: 10.1186/S12967-015-0531-Z
关键词:
摘要: The treatment of cancer is becoming more precise, targeting specific oncogenic drivers with targeted molecular therapies. epidermal growth factor receptor has been found to be over-expressed in a multitude solid tumours. Immunohistochemistry widely used the fields diagnostic and personalised medicine localise visualise disease proteins. To date clinical utility immunohistochemistry determining monoclonal antibody efficacy remained somewhat inconclusive. lack an agreed reproducible scoring criteria for has, various trials yielded conflicting results as use assay companion diagnostic. This resulted this test being removed from licence drug panitumumab not performed practice cetuximab. In review we explore reasons behind particular emphasis on colorectal cancer, suggest way resolving situation through improving precision quantitative image analysis digitised images complemented morphological techniques such situ hybridisation section based gene mutation analysis.
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