Biomonitoring and Nonpersistent Chemicals—Understanding and Addressing Variability and Exposure Misclassification

摘要: Purpose of review We offer here a intraindividual variability in urinary biomarkers for assessing exposure to nonpersistent chemicals. provide thoughts on how better evaluate Recent findings summarized reported values intraclass correlation coefficients and found that most fall into categories indicate only poor good reproducibility. Even within the "good" classification, large percentage study participants is likely be misclassified as their exposure. There sufficient information support statement studies using one spot measurement chemical will unreliable. It unequivocal multiple samples have collected over period toxicological relevance with consideration patterns. Sponsors research researchers themselves should vocal about ensuring resources are made available properly characterize exposures when studying Otherwise, we continue see an ever-growing body literature yielding inconsistent and/or uninterpretable results.