Oral tremor induced by galantamine in rats: a model of the parkinsonian side effects of cholinomimetics used to treat Alzheimer's disease.

摘要: Abstract Anticholinesterases are the most common treatment for Alzheimer's disease, and, in recent years, a new group of cholinesterase inhibitors (i.e. rivastigmine, galantamine, and donepezil) has become available. Although these drugs improve cognitive symptoms, they also can induce or exacerbate parkinsonian including tremor. The present studies were conducted to determine if galantamine induces tremulous jaw movements, rodent model tremor, investigate whether oral motor impairments be reversed by co-administration adenosine A2A antagonists. first experiment demonstrated that systemic injections (0.75–6.0 mg/kg I.P.) induced dose-related increase movements rats. In second study, muscarinic antagonist scopolamine (0.0156–0.25 mg/kg produced dose dependent suppression 3.0 mg/kg indicating through actions on acetylcholine receptors. two additional studies, analyses freeze-frame video electromyographic activity recorded from lateral temporalis muscle indicated local frequency galantamine-induced occurs 3–7 Hz range is characteristic final experiment, MSX-3 significantly attenuated which consistent with hypothesis antagonists may beneficial reducing anticholinesterase treatment.