Relationship between sexual satiety and motivation, brain androgen receptors and testosterone in male mandarin voles
作者： Fengqin He , Peng Yu , Ruiyong Wu
DOI: 10.1016/J.BBR.2013.05.022
关键词:
摘要: Androgen receptors participate in the neuroendocrine regulation of male sexual behavior, primarily brain areas located limbic system. Males many species present a long-term inhibition behavior after several ejaculations, known as satiety. It has been shown rats that androgen receptor expression is reduced 24h single ejaculation, or mating to satiety, medial preoptic area, nucleus accumbens and ventromedial hypothalamus. The aim this study was analyze these processes another animal, mandarin vole (Microtus mandarinus). We compared differences (AR) testosterone (T) various between voles sexually satiated those exposed receptive females but not allowed mate. Sexual satiety associated with decreased AR T lateral septal (LS), amygdala (MeA), area (mPOA) hypothalamic (VMH). showed an increase bed stria terminalis (BNST), LS, MeA VMH. Serum levels remained unchanged males mated These data suggest relationship activity decrease specific areas, motivation increased other independently levels.
elsevier.com
sci-hub.se 参考文章(63)
He, Fadao, Tai, Fengqin, Mating behavior induces changes of expression of Fos protein,plasma testosterone and androgen receptors in the accessory olfactory bulb （AOB） of the male mandarin vole Microtus mandarinus 动物学报. pp. 288- 295 ,(2009)
J A Kemppainen, M V Lane, M Sar, E M Wilson, Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones. Journal of Biological Chemistry. ,vol. 267, pp. 968- 974 ,(1992) , 10.1016/S0021-9258(18)48380-9
A J Syms, J S Norris, W B Panko, R G Smith, Mechanism of Androgen-receptor Augmentation ANALYSIS OF RECEPTOR SYNTHESIS AND DEGRADATION BY THE DENSITY-SHIFT TECHNIQUE* Journal of Biological Chemistry. ,vol. 260, pp. 455- 461 ,(1985) , 10.1016/S0021-9258(18)89753-8
Petteri Nieminen, Anne-Mari Mustonen, Pirjo Lindström-Seppä, Virve Kärkkäinen, Helena Mussalo-Rauhamaa, Jussi V.K. Kukkonen, Phytosterols affect endocrinology and metabolism of the field vole (Microtus agrestis). Experimental Biology and Medicine. ,vol. 228, pp. 188- 193 ,(2003) , 10.1177/153537020322800209
David de Wied, Michaela Diamant, Mariann Fodor, Central nervous system effects of the neurohypophyseal hormones and related peptides. Frontiers in Neuroendocrinology. ,vol. 14, pp. 251- 302 ,(1993) , 10.1006/FRNE.1993.1009
Shannon M Harding, Marilyn Y McGinnis, Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors. Physiology & Behavior. ,vol. 81, pp. 671- 680 ,(2004) , 10.1016/J.PHYSBEH.2004.03.008
GAIL S. PRINS, LYNN BIRCH, GEOFFREY L. GREENE, Androgen receptor localization in different cell types of the adult rat prostate. Endocrinology. ,vol. 129, pp. 3187- 3199 ,(1991) , 10.1210/ENDO-129-6-3187
Gerianne M. Alexander, Melissa Hines, Mark G. Packard, Testosterone has rewarding affective properties in male rats : implications for the biological basis of sexual motivation Behavioral Neuroscience. ,vol. 108, pp. 424- 428 ,(1994) , 10.1037//0735-7044.108.2.424
W VANFURTH, G WOLTERINK, J VANREE, Regulation of masculine sexual behavior: involvement of brain opioids and dopamine Brain Research Reviews. ,vol. 21, pp. 162- 184 ,(1995) , 10.1016/0165-0173(96)82985-7
Di Wu, Andrea C. Gore, Changes in androgen receptor, estrogen receptor alpha, and sexual behavior with aging and testosterone in male rats Hormones and Behavior. ,vol. 58, pp. 306- 316 ,(2010) , 10.1016/J.YHBEH.2010.03.001