Blood–brain barrier pathophysiology in brain tumors
作者： Gerardo Caruso , Lucia Merlo , Maria Caffo
关键词:
摘要: In this chapter we will focus on the blood–brain barrier physiological structure and subsequent pathophysiology in presence of brain tumors. The existence selectively prevents free passage numerous molecules, especially macromolecules such as many drugs are. tightness is due to its non-fenestrated endothelial cells junctional structure; transmembrane proteins sealing intercellular cleft also plays a pivotal role selective substances. pathological process, inflammation or tumors, undergoes modifications permeability. It thorough study functioning both settings that can be key interfering with permeability, so allowing drugs.
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