Long-acting interferon, preparation method therefor and applications thereof

摘要: The invention belongs to the biological pharmacy field, and relates a long-acting interferon, preparation method therefor applications thereof. interferon comprises polysialic-acid-modified recombination fusion protein. polysialic acid is subjected activation by utilization of sodium periodate. activated reacts with an form conjugate in presence cyanoborohydride. protein composed N-end C-end naturally-existed hydrophilic polypeptides without repeated sequences. can be expressed escherichia coli high efficiency, technology simple used for production large-scale medicine-level proteins. treatment virus infectious diseases hepatitis virus, SARS, herpes simplex like, malignant tumors neuroglioma, lung cancer like other cell proliferative diseases.