Cassette vectors directing expression of T cell receptor genes in transgenic mice
作者： Valérie Kouskoff , Kathy Signorelli , Christophe Benoist , Diane Mathis
DOI: 10.1016/0022-1759(95)00002-R
关键词:
摘要: We describe a pair of cassette vectors that can be used to express rearranged T cell receptor genes in transgenic mice. Short DNA fragments containing V alpha and beta segments are readily amplified from cells introduced between artificial cloning sites. Transgene-derived mRNAs transcribed under the control natural TCR -beta promoter/enhancer elements. Using this vector, we have obtained mouse lines which display transgene-encoded chains on majority cells.
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