Pancreatic lipase inhibitory activity of monogalactosyldiacylglycerols isolated from the freshwater microalga Chlorella sorokiniana
作者： Arjun H. Banskota , Aaron J. Steevensz , Roumiana Stefanova , Sandra Sperker , Ronald Melanson
DOI: 10.1007/S10811-015-0558-9
关键词:
摘要: Chemical investigation of the freshwater microalga Chlorella sorokiniana led to isolation a monogalactosyldiacylglycerol (MGDG)-rich fraction possessing dose-dependent inhibitory activity against pancreatic lipase activity. The MGDG-rich contains 12 MGDGs identified by LC/HRMS analysis. Among them, three were new compounds, namely, (2S)-1-O-(7Z,10Z-hexadecadienoyl)-2-O-(7Z,10Z,13Z-hexadecatrienoyl)-3-O-β-D-galactopyranosylglycerol (1), (2S)-1-O-linoleoyl-2-O-(7Z,10Z-hexadecadienoyl)-3-O-β-D-galactopyranosylglycerol (6), and (2S)-1-O-oleoyl-2-O-(7Z,10Z-hexadecadienoyl)-3-O-β-D-galactopyranosylglycerol (8). major galactolipids isolated semipreparative HPLC tested for their effect toward All showed significant reduction indicating possible beneficial use management lipase-related disorders such as obesity.
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