Molecular Genetics of the Acquired Long QT Syndrome

摘要: The previous chapter has outlined the clinical conditions under which arrhythmias occur in patients with congenital long QT syndrome (LQTS). One such condition - identified only a handful of to date — is administration QT-prolonging drug; this finding indicates that form LQTS and drug-associated overlap. Moreover, as availability molecular genotyping expands, individuals mutations disease genes no manifest phenotype are being identified, anecdotal data also support contention drug may unmask genotype by provoking Torsades de Pointes (TdP). More generally, it seems increasingly clear abnormal repolarization common feature acquired heart disease, play role development diverse settings, failure (1), hypertrophy (2), or atrial fibrillation (3). It goal outline genetic factors determining cardiac “acquired” syndrome, i.e. provoked drugs presence disease.