Systematic review with meta-analysis: global prevalence of uninvestigated dyspepsia according to the Rome criteria.

摘要: BACKGROUND Prevalence of uninvestigated dyspepsia varies across cross-sectional surveys. This may be due to differences in definitions used or study methodology, rather than global variability. AIM To determine the prevalence according Rome criteria. METHODS MEDLINE and EMBASE were searched identify population-based studies reporting adults (≥18 years old) I, II, III IV was extracted, criteria define it. Pooled prevalence, location certain other characteristics, odds ratios (OR), 95% confidence intervals (CIs) calculated. RESULTS Of 2133 citations evaluated, 67 fulfilled eligibility criteria, representing 98 separate populations, comprising 338 383 subjects. ranged from 17.6% (95% CI 9.8%-27.1%) defining I 6.9% 5.7%-8.2%) those using Postprandial distress syndrome commonest subtype, occurring 46.2% participants 62.8% with IV. up 1.5-fold higher women, irrespective definition used. There significant heterogeneity between all our analyses, which persisted even when same applied similar methodology CONCLUSIONS Even uniform symptom-based are presence dyspepsia, countries. suggests that there environmental, cultural, ethnic, dietary genetic influences determining symptoms.