Mutational Analysis of the Candidate Tumor Suppressor Genes TEL and KIP1 in Childhood Acute Lymphoblastic Leukemia

摘要: Abstract We have shown previously that loss of heterozygosity at chromosome band 12p13 is among the most frequent genetic abnormalities identified in acute lymphoblastic leukemia (ALL) childhood. Two known genes map within critically deleted region 12p: TEL, gene encoding a new member ETS family transcription factors, which rearranged variety hematological malignancies; and KIP1, cyclin-dependent kinase inhibitor p27. Both are, therefore, excellent candidate tumor suppressor genes. In this report, we determined exon organization TEL performed mutational analysis KIP1 33 childhood ALL patients to locus. No mutations either or were found; suggests neither nor critical 12p ALL.