Theoretical modeling and experimental evaluation of a microscale molecular mass sensor.

摘要: A theoretical model for a recently developed microscale molecular mass sensor (μ-MMS) is presented. The μ-MMS employs widely applicable technique of measuring the refractive index gradient (RIG) in microchannel created after two adjacent streams merge:  “sample stream” containing analyte(s) interest host solvent and “mobile-phase” stream only solvent. Because flow laminar, analytes sample mix with mobile-phase primarily by diffusion. diffusion-induced RIG measured monitoring deflection angle diode laser probe beam, which orthogonal to both direction analyte samples beams at positions along flow, ratio downstream upstream signal monitors diffusion coefficient. Following calibration given class compounds, an interest...