Clinical efficacy of Rong-Yang-Jyh-Gan-Tang on patients with chronic hepatitis C: A double-blinded randomized placebo-controlled crossover study.

摘要: Abstract Ethnopharmacological relevance Traditional Chinese medicine (TCM) has been widely used by the population for treatment of chronic hepatitis. However, efficacy TCM patients with hepatitis not confirmed, mostly due to lack available scientific parameters such as serum viral load evaluate response. Aim study We evaluated Rong-Yang-Jyh-Gan-Tang (RYJGT, composed Long-Dan-Xie-Gan-Tang, Jia-Wei-Xia-Yao-San, Dan-Shen, and Hou-Po) on C. Materials methods Thirty-six C who had no response or contraindications interferon-ribavirin therapy were randomly allocated receive RYJGT 15 g/day placebo 12 weeks. After a 2-week washout period, crossed over another Evaluation included liver biochemistries, HCVRNA, side effects RYJGT/placebo, symptoms. Results Of 12-week treatment, 51.7% decreased HCVRNA levels, whereas only 25.8% levels in group ( p =0.036). patterns “Damp-Heat” “Liver Qi Depression” significantly improved after comparison placebo. Logistic analyses showed that pre-treatment values symptoms Depression”, statistically significant factors predicting decrease HCVRNA. Conclusion Chronic received higher ratio, than those Our results require further larger scale clinical trials.