Risk of Cervical Intraepithelial Neoplasia 2 or Worse by Cytology, Human Papillomavirus 16/18, and Colposcopy Impression: A Systematic Review and Meta-analysis

摘要: Objective To calculate pooled risk estimates for combinations of cytology result, human papillomavirus (HPV) 16/18 genotype and colposcopy impression to provide a basis risk-stratified biopsy practice. Data source A PubMed search was conducted on June 1, 2016, ClinicalTrials.gov 9, 2018, using key words such as "uterine cervical neoplasms," "cervical cancer," "mass screening," "early detection "colposcopy." Methods study selection Eligible studies must have included colposcopic either results or HPV partial well histologic diagnosis from adult women. Manuscripts were reviewed the following: cytology, status, age, number women, intraepithelial neoplasia (CIN) 2, CIN 3, cancer cases. Strata defined by various genotype, impression. Tabulation, integration, Of 340 abstracts identified, nine eligible inclusion. also obtained three unpublished studies, two which since been published. We calculated 2 worse 3 based colposcopy, test results. found similar patterns across in lowest groups that despite different referral populations designs. Women with normal (no acetowhitening), less than high-grade squamous lesion 16/18-negative at low prevalent precancer. least HPV16- HPV18-positive, highest Conclusion Our support risk-based approach modifications practice levels.