Arguments for the sake of endophenotypes: Examining common misconceptions about the use of endophenotypes in psychiatric genetics

作者: David C. Glahn , Emma E.M. Knowles , D. Reese McKay , Emma Sprooten , Henriette Raventós

DOI: 10.1002/AJMG.B.32221

关键词:

摘要: … lack of understanding of pathophysiology and gene regulation. However, despite the potential utility of endophenotypes for … In the sections that follow, we address and clarify some of the …

参考文章(78)
Vincent P. Diego, Thomas D. Dyer, Marcio Almeida, Juan Peralta, Jack W. Kent, Jeff T. Williams, Laura Almasy, Harald H.H. Göring, A Kernel of Truth Advances in Genetics. ,vol. 81, pp. 1- 31 ,(2013) , 10.1016/B978-0-12-407677-8.00001-4
J. T. WILLIAMS, J. BLANGERO, Power of variance component linkage analysis-II. Discrete traits. Annals of Human Genetics. ,vol. 68, pp. 620- 632 ,(2004) , 10.1046/J.1529-8817.2004.00128.X
Jerald P. Radich, Mao Mao, Sergey Stepaniants, Matt Biery, John Castle, Terry Ward, Greg Schimmack, Sumire Kobayashi, Michael Carleton, Johanna Lampe, Peter S. Linsley, Individual-specific variation of gene expression in peripheral blood leukocytes. Genomics. ,vol. 83, pp. 980- 988 ,(2004) , 10.1016/J.YGENO.2003.12.013
Emma Sprooten, Jessika E. Sussmann, April Clugston, Anna Peel, James McKirdy, T. William J. Moorhead, Seonaid Anderson, Allen J. Shand, Stephen Giles, Mark E. Bastin, Jeremy Hall, Eve C. Johnstone, Stephen M. Lawrie, Andrew M. McIntosh, White Matter Integrity in Individuals at High Genetic Risk of Bipolar Disorder Biological Psychiatry. ,vol. 70, pp. 350- 356 ,(2011) , 10.1016/J.BIOPSYCH.2011.01.021
Thomas Insel, Bruce Cuthbert, Marjorie Garvey, Robert Heinssen, Daniel S. Pine, Kevin Quinn, Charles Sanislow, Philip Wang, Research domain criteria (RDoC): toward a new classification framework for research on mental disorders American Journal of Psychiatry. ,vol. 167, pp. 748- 751 ,(2010) , 10.1176/APPI.AJP.2010.09091379
J. Blangero, J. T. Williams, L. Almasy, Novel family-based approaches to genetic risk in thrombosis Journal of Thrombosis and Haemostasis. ,vol. 1, pp. 1391- 1397 ,(2003) , 10.1046/J.1538-7836.2003.00310.X
Eve C. Johnstone, Stephen M. Lawrie, Richard Cosway, What does the Edinburgh high-risk study tell us about schizophrenia? American Journal of Medical Genetics. ,vol. 114, pp. 906- 912 ,(2002) , 10.1002/AJMG.B.10304
Doug Speed, Gibran Hemani, Michael R. Johnson, David J. Balding, Improved Heritability Estimation from Genome-wide SNPs American Journal of Human Genetics. ,vol. 91, pp. 1011- 1021 ,(2012) , 10.1016/J.AJHG.2012.10.010
Sohee Park, Philip Holzman, P Goldman-Rakic, Spatial Working Memory Deficits in the Relatives of Schizophrenic Patients Archives of General Psychiatry. ,vol. 52, pp. 821- 828 ,(1995) , 10.1001/ARCHPSYC.1995.03950220031007
DORINE SLAATS-WILLEMSE, HANNA SWAAB-BARNEVELD, LEO de SONNEVILLE, EMMA van der MEULEN, JAN BUITELAAR, Deficient Response Inhibition as a Cognitive Endophenotype of ADHD Journal of the American Academy of Child and Adolescent Psychiatry. ,vol. 42, pp. 1242- 1248 ,(2003) , 10.1097/00004583-200310000-00016