Impaired blood supply in the colonic anastomosis in mice compromises healing.

摘要: Abstract Colon anastomotic leakage has a multifactorial etiology and ischemia is considered one of the most important single factors. However, no existing animal models have established direct link between leakage. The aim this study was to establish model colon as result tissue ischemia. In anastomoses 53 C57BL/6 mice, varying degrees were induced. Supplying vessels divided with bipolar coagulation in order reduce breaking strength create clinical Breaking all ischemic significantly lower compared controls. Increasing resulted higher rates large bowel obstruction without creating Healing compromised impaired blood supply. absent. Pure otherwise healthy experimental animals may be too simple an approach