Estimating the hazards of less hazardous cigarettes. II. Study of cigarette yields of nicotine, carbon monoxide, and hydrogen cyanide in relation to levels of cotinine, carboxyhemoglobin, and thiocyanate in smokers.

摘要: Yields of chemical constituents such as tar, nicotine, CO, and HCN defined by smoking machines are commonly assumed to provide a reasonable indication the relative hazard associated with given brand cigarette. Results reported here suggest that this assumption should be carefully reexamined. A total 240 subjects, representing wide range characteristics, were recruited for an investigation possible relations between yields exposure (levels carboxyhemoglobin, breath plasma cotinine, thiocyanate, saliva thiocyanate). Exposure was highly correlated consumption (number cigarettes per day), but there no correlation any estimate yield when level held constant. In addition, comparison levels carboxyhemoglobin thiocyanate 16 smokers “low‐hazard” 15 “high‐hazard” cigarette brands revealed little difference two groups, even though a...